Calmodulin Bound Aquaporin-0 Reveals Two Distinct Energy Profiles
نویسندگان
چکیده
منابع مشابه
Noncanonical binding of calmodulin to aquaporin-0: implications for channel regulation.
Aquaporins (AQPs) are a family of ubiquitous membrane channels that conduct water across cell membranes. AQPs form homotetramers containing four functional and independent water pores. Aquaporin-0 (AQP0) is expressed in the eye lens, where its water permeability is regulated by calmodulin (CaM). Here we use a combination of biochemical methods and NMR spectroscopy to probe the interaction betwe...
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We previously showed that the water permeability of AQP0, the water channel of the lens, increases with acid pH and that His40 is required (Németh-Cahalan, K.L., and J.E. Hall. 2000. J. Biol. Chem. 275:6777-6782; Németh-Cahalan, K.L., K. Kalman, and J.E. Hall. 2004. J. Gen. Physiol. 123:573-580). We have now investigated the effect of zinc (and other transition metals) on the water permeability...
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ژورنال
عنوان ژورنال: Computational Molecular Bioscience
سال: 2016
ISSN: 2165-3445,2165-3453
DOI: 10.4236/cmb.2016.64006